Pharmacogenomics and Genomic Medicine Group

Phone: +233 594972150 | Email: nthomford@ucc.edu.gh/nicholas.thomford@uct.ac.za

PUBLICATION

We are a research group that is made of researchers from different disciplines bringing their expertise to undertake research projects in pharmacogenomics…

Selected publications

2024

Thomford, N.E., Kellermann, T., Biney, R.P. et al. Therapeutic efficacy of generic artemether–lumefantrine in the treatment of uncomplicated malaria in Ghana: assessing anti-malarial efficacy amidst pharmacogenetic variations. Malar J 23, 125 (2024). https://doi.org/10.1186/s12936-024-04930-1

Thomford N.E., Abraham S.A., Nyarko Badu S., Biney R.P. A consideration of CYP2D6 genetic variations in the Ghanaian population as a potential ‘culprit’ for the tramadol “abuse crisis”. BMC Medical Genomics, 2024, 17:28, 1 6.https://doi.org/10.1186/s12920-023-01773-8

 

2023

Thomford N.E., Adu F., Gavor-Kwashi C., Nyarko S.B., Nsiah P., Ephraim R.D., Adjei G., Anyanful A. An exploratory pharmacogenetic screening of SLC22A6, SLC22A8, ABCC4 and ABCC10 genes in a cohort of Ghanaian HBV patients. Egyptian Journal of Medical Human Genetics. 2023 24:50. https://doi.org/10.1186/s43042-023-00428-8

Thomford NE, Dampson FN, Adjei G, Eliason S, Ekor M, Kyei GB. Psychometric assessment of hiv stigma in patients attending a tertiary facility: an initial validation of the Berger HIV stigma scale in a Ghanaian perspective. PLoS ONE 18(4): e0282193. https://doi.org/10.1371/ journal.pone.0282193

Thomford NE, Anyanful A, Ateko RO, Blackhurst D, Biney RP, Boadi D,  Nyarko SB, Ekor M, Kyei GB. Apolipoprotein E genetic variation, atherogenic index and cardiovascular disease risk assessment in an African population: An analysis of HIV and malaria patients in Ghana. PLoS ONE 18(5): e0284697. https://doi.org/10.1371/journal. pone.0284697

Osafo C., Thomford N.E., Coleman J., Carboo A., Guure C., Okyere P, et al. (2022) APOL1 genotype associated risk for preeclampsia in African populations: Rationale and protocol design for studies in women of African ancestry in resource limited settings. PLoS ONE. 2023 17(12): e0278115. https://doi.org/10.1371/journal. pone.0278115

Sarpong E, Acheampong D.O., Fordjour G.N.R., Anyanful A., Aninagyei E., Tuoyire D.A., Blackhurst D., Kyei G.B., Ekor M., Thomford N.E. Zero malaria: A mirage or reality for a population of sub-Saharan Africa in health transition. Malaria Journal. 2022. 21(1),314

2022

Osafo C, Thomford NE, Coleman J,Carboo A, Guure C, Okyere P, et al. (2022) APOL1 genotype associated risk for preeclampsia in African populations: Rationale and protocol design for studies in women of African ancestry in resource limited settings. PLoS ONE 17(12): e0278115. https://doi.org/10.1371/journal. pone.0278115

2021

Kuguyo O., Dube Mandishora R.S., Thomford N.E., Makunike-Mutasa R., Nhachi C.F.B., Matimba A., Dandara C. High-risk HPV genotypes in Zimbabwean women with cervical cancer: Comparative analyses between HIV-negative and HIV-positive women. PLoS One. 2021; 16(9):e0257324. doi:10.1371/journal.pone.0257324. eCollection 2021

Adjei G., Enuameh Y.A., Thomford N.E. Prevalence of COVID-19 genomic variation in Africa: a living systematic review protocol. JBI Evid Synth. 2021 Aug 2. doi: 10.11124/JBIES-20-00516 2020

Thomford N.E., Mhandire D., Dandara C., Kyei G.B. Promoting Undetectable Equals Untransmittable in Sub-Saharan Africa: Implication for Clinical Practice and ART Adherence. Int J Environ Res Public Health. 2020 Aug 25;17(17): E6163. doi: 10.3390/ijerph17176163.

Thomford N.E., Yahaya E.S., Ekor M., Awortwe C. Turning Up the Volume for Precision Herbal Medicine in Africa in an Era of COVID-19 and Planetary Biodiversity Loss. OMICS. 2020 Aug 21. doi: 10.1089/omi.2020.0150.

Thomford, N. E., Biney, R. P., Okai, E., Anyanful, A., Nsiah, P., Frimpong, P. G., . . . Wonkam, A. (2020). Clinical Spectrum of congenital heart defects (CHD) detected at the child health Clinic in a Tertiary Health Facility in Ghana: a retrospective analysis. BMC Journal of Congenital Cardiology, 4(1), 3. doi:10.1186/s40949-020-00034-y Yılmaz S.G., Bozkurt H., Ndadza A.,

Thomford N.E., Karaoğlan M., Keskin M., Benlier N.,Dandara. Childhood obesity risk in relation to circulating miRNAs targeting the perilipin 1 (PLIN1) gene. OMICS: A journal of integrative biology 24(1):43-50. doi: 10.1089/omi.2019.0150. Epub 2019

2019

Thomford N.E., Bope C.D., Agamah F.E., Dzobo K., Owusu Ateko R., Chimusa E., Mazandu G.K., Ntumba S.B., Dandara C., Wonkam A. Implementing Artificial Intelligence and Digital Health in Resource-Limited Settings? Top 10 Lessons We Learned in Congenital Heart Defects and Cardiology. OMICS: A journal of integrative biology doi: 10.1089/omi.2019.0142 Dandara C., Thomford N.E., Tashinga E.B. Herbal Remedies: Throwing Off Phenotype Prediction—A Culprit for Pharmacogenomic‐Guided Drug Therapy and Drug Safety. Clin Pharmacol Ther. 106(2):302-304. doi: 10.1002/cpt.1509

 

Awany D., Allali I., Dalvie S., Hemmings S., Mwaikono K.S., Thomford N.E., Gomez A., Mulder N. and Chimusa E.R. Host and Microbiome Genome-Wide Association Studies: Current State and Challenges. Front. Genet. 2019. 9:637. doi: 10.3389/fgene.2018.00637

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